INTERVENTIONS All patients received supplemental oxygen endotracheal intubation was performed, and synchronized intermittent mandatory ventilation was initiated whenever it was deemed necessary. The first 31 patients were studied in a double-blind fashion, while the rest of the patients were given flumazenil according to an open protocol. Unconscious patients (n = 110) suspected of benzodiazepine overdose, graded 2 to 4 on the Matthew and Lawson coma scale, were treated with flumazenil, the specific benzodiazepine receptor antagonist. other drug-induced coma), and to reverse or prevent the recurrence of unconsciousness.Ī two-phase study: a controlled, randomized, double-blind study followed by a prospective, open study.Īn 800-bed, teaching, university-affiliated hospital. To assess the efficacy, usefulness, safety, and dosages of flumazenil required when flumazenil is used in the diagnosis of benzodiazepine-induced coma (vs.
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